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Lipid Excipients for Pharmaceutical Liposome

A number of liposome-based drug formulations are available in market, the liposomes for adriamycin are Doxil®, Myocet®, DaunoXome®;  for  Amphotericin B are Abelcet®,  Ambisome®,  Amphotec®;  The micelle for Paclitaxel are Cynviloq™, Genexol-PM®
Catalog Number: Lipid for pharmaceutical liposome
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  • Description
Due to extensive developments in liposome technology in the recent years, a number of liposome-based drug formulations are available in the clinic market and many products are undergoing different clinical trials.  Among them, the liposomes for Adriamycin are Doxil®, Myocet®, DaunoXome®;  for  Amphotericin B are Abelcet®,  Ambisome®,  Amphotec®,for Irinotecan is Onivyde®; the micelle for Paclitaxel are Cynviloq,  Apealea®,  Genexol-PM®; the lipid complex for siRNA is ONPATTRO®.
Liposome preparation
  DoxilGenexol-PMMyocetPEGylated Liposome
Doxil®              Adriamycin/mL: HSPC: CHOL: DSPE-mPEG2000=2mg: 9.58mg: 3.19mg: 3.19mg; Excipients: Ammonia Sulfate 2mg Histidine 1.55mg Sucrose 94mg

Ambisome®      Amphotericin B: HSPC: CHOL: DSPG=50mg: 213mg: 52mg: 84mg; Excipients: α-Tocopherol 0.64mg Disodium succinate hexahydrate 27mg Sucrose 900mg Water 12mL

Abelcet®          Amphotericin B/mL: DMPC: DMPG=5.0mg: 3.4mg: 1.5mg; Excipients: Sodium Chloride: 9.0mg

Amphotec®      Amphotericin B: Cholesteryl sodium sulfate: Trometamol =50mg: 26.4mg: 5.64mg; Excipients: Disodium edetate 0.372mg Lactose Monohydrate 950mg Water10ml

Genexol-PM®  Paclitaxel: mPEG-PLA=30mg: 150mg

Abraxane®       Paclitaxel: Human Albumin=100mg: 900mg
Name Description Purity
DSPE-mPEG2000 Methoxypolyethylene glycol DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine) ≥99.0%
HSPC L-α-phosphatidylcholine, hydro genated (Soy) ≥99.0%
DSPG 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, sodium salt ≥99.0%
DSPC 1,2-Distearoyl-sn-glycero-3-phosphocholine ≥99.0%
DMPC 1,2-dimyristoyl-sn-glycero-3-phosphocholine ≥99.0%
DMPG 1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) ≥99.0%
CHO Cholesterol ≥99.0%
Cholesteryl Sulfate Cholesteryl sodium sulfate ≥99.0%
PEG-b-PLA Monomethoxy-Poly(ethylene glycol)-block-poly(d,l-lactic acid) Quote
Adriamycin Active ingradient in Doxil®, Myocet®, DaunoXome®  ≥99.0%
Paclitaxel Active ingradient in Abelcet®,  Ambisome®,  Amphotec®  ≥99.0%
Amphotericin B Active ingradient in Cynviloq,  Apealea®,  Genexol-PM®  ≥99.0%
Genizer Liposome Extruder System
Catalog No. Thermo-control Power mode Maximum pressure
Hand Extruder HandExtruder-1mL None Hand Drive 150 psi
HandExtruder-1mL-RT Jacketed Hand Drive 150 psi
Jacketed Extruder GJE-10mL Jacketed Compressed Gas 3000psi
GJE-100mL Jacketed Compressed Gas 3000psi
GJE-800mL Jacketed Compressed Gas 3000psi
GJE-3000mL Jacketed Compressed Gas 3000psi
GJE-10000mL Jacketed Compressed Gas 3000psi
Online Extruder GOE-25mL Jacketed Online Pump 6000psi
GOE-200mL Jacketed Online Pump 6000psi
GOE-1000mL Jacketed Online Pump 6000psi
GOE-8L Jacketed Online Pump 6000psi
GOE-20L Jacketed Online Pump 6000psi
Multi Extruder GOE-8L*2 Jacketed Online Pump 6000psi
GOE-8L*4 Jacketed Online Pump 6000psi
GOE-8L*8 Jacketed Online Pump 6000psi